Millimeter Brain Implant Treats Depression as Outpatient Procedure

Motif Neurotech's pea-sized DOT microstimulator safely delivered brain stimulation for treatment-resistant depression without contacting neural tissue, according to intraoperative data published to Medrxiv. The Houston company's contactless approach eliminates craniotomy, enabling outpatient implantation rather than major surgery. The $18.75 million funding round follows animal studies showing sustained safety beyond 30 days. Expanded access to neuromodulation therapy hinges on proving long-term efficacy in full clinical trials.