Up Against It centres on parents told Rose may need sibling donor

Up Against It follows estranged parents Álvaro and Saffron, told their daughter Rose may need a sibling as a potential donor to survive, according to Variety. Antonio Banderas and Eva Birthistle star, with Eden Hamilton as Rose, according to Variety. Trudie Styler directs, according to Variety. It premieres Sept. 12 at the Toronto International Film Festival, according to Variety.